Abstract
Biopsies of skeletal muscle collected from 24 animals classified as “double muscled” were examined by light and electron microscopy. The muscle samples exhibited degenerative changes including the presence of vacuolations and lamellated structures, fragmentation of myofibers, accumulation of glycogen granules, disruption of neuromuscular junctions and disorganization of the sarcolemma. In the light of the excessive fragility of the erythrocyte membranes noted previously, the alteration in the sarcolemma suggests that a generalized cell membrane defect may be the most consistent feature of the “double muscling syndrome” in cattle.
Keywords: ultrastructure, hereditary muscular hypertrophy, cattle
Sammanfattning
Skelettmuskelbiopsier från 24 djur klassificerade som “double muscled” undersöktes med ljus- och elektronmikroskop. Muskelproverna visade degenerativa förändringar omfattande vakuolisering och uppträdande av lamellartade figurer, ansamling av glykogenkorn, uppsplittring av muskelfibrerna, isärsprängning av nerv-muskelförbindelser samt desorganiserat sarcolemma. Med tanke på den extrema känslighet som tidigare observerats i erythrocytmembranet antyder förändringarna i sarcolemmat att en generell membrandefekt kan vara det mest genomgående draget i “the double muscling syndrome” hos nötkreatur.
Full Text
The Full Text of this article is available as a PDF (3.0 MB).
Footnotes
The investigation was supported in part by a grant from the National Research Council of Canada (to P. K. Basrur).
References
- Hendricks H B, Aberle E D, Jones D J, Martin T G. Muscle fiber type, rigor development and bone strength in double muscled cattle. J. Anim. Sci. 1973;37:1305–1311. doi: 10.2527/jas1973.3761305x. [DOI] [PubMed] [Google Scholar]
- Holmes, J. H. G. & C. R. Ashmore: A histochemicai study of development of muscle fiber type and size in normal and double muscled cattle. Growth 1972, 36, 351–372, [PubMed]
- Holmes, J. H. G., D. W. Robinson & C. R. Ashmore: Blood lactic acid and behaviour in cattle with hereditary muscular hypertrophy. J. Anim. Sci. 1972 a, 35, 1011–1013. [DOI] [PubMed]
- Holmes, J. H. G., C. R. Ashmore, D. W. Robinson, J. P. Finn & J. O’Dell: A condition resembling “Azoturia” in a “double muscled” heifer. Vet. Rec. 1972 b, 90, 625–630. [DOI] [PubMed]
- Jubb, K. U. P. & P. C. Kennedy: Pathology of Domestic Animals. Vol. 2. Acad. Press, New York 1070.
- Kieffer, N. M., T. C. Cartwright & J. E. Sheek: Characterization of the double muscled syndrome: I. Genetics, p. 38–43. In Beef Cattle Research in Texas, 1972. (Miller, J. E., Director) Texas, A and M Univ. System 1972.
- King, W. A.: Hereditary muscular hypertrophy (double muscling) in beef cattle. MSc Thesis, Univ. Guelph 1975.
- King W A, Basrur P K, Brown R G, Berg R T. Osmotic response test on erythrocytes for the detection of double muscle carrier in cattle. Ann. Génét. Sél. Anim. 1976;8:41–45. doi: 10.1186/1297-9686-8-1-41. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oliver, W. M. & T. C. Cartwright: Double muscling in cattle, a review of expression, genetics and economic implications. Texas A and M. Univ. Tech. Rep. 1969, 12.
- Rollins, W. C., M. Tanaka, C. F. G. Nott & R. B. Thieson: On the mode of inheritance of double muscle conformation in bovines. Hilgardia 1972., 41, 436–456.
- Sopena Q A, Blanco C. Culard mode of inheritance. Zootechnia (Madr.) 1972;19:501–522. [Google Scholar]
- Swatland H J. Innervation of genetically enlarged muscles from double muscled cattle. J. Anim. Sci. 1973;36:355–362. doi: 10.2527/jas1973.362355x. [DOI] [PubMed] [Google Scholar]
- Vissac B. Etude du caractère culard. II: Incidence du caractère culard sur la morphologie général des bovines. (Study of the “double rump” in cattle. II. Morphological characteristics) Ann. Zootech. 1968;17:77–101. doi: 10.1051/animres:19680107. [DOI] [Google Scholar]