Table 1.
The top 10 dysregulated biological pathways at immediate (2 h), early (26 h) and late (day 4) response in IC following acute H2S exposure.
| Immediate response | Unfolded protein response | 1.05E-06 | |
| Immediate response | Catecholamine Biosynthesis | 6.72E-05 | |
| Immediate response | Coagulation System | 2.48E-04 | |
| Immediate response | GADD45 Signaling | 1.25E-03 | |
| Immediate response | Dopamine Receptor Signaling | 3.73E-03 | |
| Immediate response | NRF2-mediated Oxidative Stress Response | 4.51E-03 | 1.342 |
| Immediate response | GABA Receptor Signaling | 7.61E-03 | 1 |
| Immediate response | Death Receptor Signaling | 9.78E-03 | 0.378 |
| Immediate response | eNOS Signaling | 1.95E-02 | 0.707 |
| Immediate response | p53 Signaling | 2.51E-02 | 2 |
| Early response | Unfolded protein response | 2.05E-07 | |
| Early response | NRF2-mediated Oxidative Stress Response | 8.26E-05 | 0.447 |
| Early response | Hypoxia Signaling in the Cardiovascular System | 8.94E-05 | 1.633 |
| Early response | Coagulation System | 2.44E-04 | −0.447 |
| Early response | Endoplasmic Reticulum Stress Pathway | 3.34E-04 | |
| Early response | Acute Phase Response Signaling | 4.74E-04 | 2.646 |
| Early response | PI3K Signaling in B Lymphocytes | 5.08E-03 | 0.816 |
| Early response | Calcium Signaling | 9.02E-03 | −0.447 |
| Early response | IL-6 Signaling | 1.80E-02 | 0.816 |
| Early response | HMGB1 Signaling | 2.20E-02 | 1.342 |
| Late response | Agranulocyte Adhesion and Diapedesis | 1.55E-10 | |
| Late response | Granulocyte Adhesion and Diapedesis | 1.08E-08 | |
| Late response | Acute Phase Response Signaling | 1.67E-07 | 2.887 |
| Late response | HMGB1 Signaling | 2.00E-07 | 2.673 |
| Late response | IL-10 Signaling | 2.18E-07 | |
| Late response | Coagulation System | 8.45E-06 | −1.134 |
| Late response | phagosome formation | 1.38E-05 | |
| Late response | IL-6 Signaling | 1.01E-04 | 1.897 |
| Late response | JAK/Stat Signaling | 4.32E-04 | 0.707 |
| Late response | PPAR Signaling | 9.24E-04 | −2.828 |
Dysregulated biological pathways were analyzed for immediate, early, and late response to H2S exposure. The top 10 dysregulated biological pathways were measured by statistical analyses and are listed. Degree of activating biological pathways is shown by the z-Score. Higher value of z-Score indicates activation of biological pathways, whereas lower value of z-Score for inactivation of biological pathways.