Table 3.
Metabolite composition of the GDM-related metabolite pattern (‘Factor 4’) identified at T1
| Metabolite | Superpathway | Subpathway | Factor loading |
|---|---|---|---|
| Palmitoyl-arachidonoyl-glycerol (16:0/20:4) [tier 2]a | Lipid | Diacylglycerol | 0.64 |
| 1-Stearoyl-GPE (18:0) | Lipid | Lysophospholipid | 0.64 |
| 1-Palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)a | Lipid | Phosphatidylcholine | 0.63 |
| 1-Myristoyl-2-arachidonoyl-GPC (14:0/20:4)a | Lipid | Phosphatidylcholine | 0.62 |
| Palmitoleoyl-arachidonoyl-glycerol (16:1/20:4) [tier 2]a | Lipid | Diacylglycerol | 0.62 |
| 1-Palmitoyl-2-arachidonoyl-GPI (16:0/20:4)a | Lipid | Phosphatidylinositol | 0.62 |
| 1-Palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine | 0.60 |
| 1-Palmitoyl-GPE (16:0) | Lipid | Lysophospholipid | 0.60 |
| Oleoyl-arachidonoyl-glycerol (18:1/20:4) [tier 1]a | Lipid | Diacylglycerol | 0.60 |
| Oleoyl-arachidonoyl-glycerol (18:1/20:4) [tier 2]a | Lipid | Diacylglycerol | 0.59 |
| Palmitoyl-oleoyl-glycerol (16:0/18:1) [tier 2]a | Lipid | Diacylglycerol | 0.59 |
| Palmitoleoyl-linoleoyl-glycerol (16:1/18:2) [tier 1]a | Lipid | Diacylglycerol | 0.59 |
| Diacylglycerol (16:1/18:2 [tier 2], 16:0/18:3 [tier 1])a | Lipid | Diacylglycerol | 0.58 |
| 1-Myristoyl-2-palmitoyl-GPC (14:0/16:0) | Lipid | Phosphatidylcholine | 0.57 |
| Palmitoyl-oleoyl-glycerol (16:0/18:1) [tier 1]a | Lipid | Diacylglycerol | 0.56 |
| 1-Palmitoleoyl-GPC (16:1)a | Lipid | Lysophospholipid | 0.54 |
| 1-Palmitoyl-GPC (16:0) | Lipid | Lysophospholipid | 0.53 |
| 1-Stearoyl-2-oleoyl-GPC (18:0/18:1) | Lipid | Phosphatidylcholine | 0.53 |
| 1-Stearoyl-2-oleoyl-GPE (18:0/18:1) | Lipid | Phosphatidylethanolamine | 0.53 |
| 1-Linolenoyl-GPC (18:3)a | Lipid | Lysophospholipid | 0.52 |
| 1-Palmitoyl-GPG (16:0)a | Lipid | Lysophospholipid | 0.51 |
a
Tier 2 identification in which no commercially available authentic standards could be found, but annotated based on accurate mass, spectral and chromatographic similarity to tier 1-identified compounds
GPG, glycerophosphoglycerol; GPI, glycosylphosphatidylinositol