Fig. 4.

Frequency of lipid classes among significant regulated lipids. Significant up (a) and down (b) regulated lipid classes for CVD versus control (n=217). Significant up (c) and down (d) regulated lipid classes for statin treated versus not-treated controls (n=85). Red bars indicate significant regulated lipid class frequencies after correction of multiple testing. Blue bars indicate significant regulated lipid class frequencies after correction of multiple testing and filtering for at least two-fold regulation Panel (a) includes sterol hemi-esters (SHE), the end product of oxidation of polyunsaturated fatty acid esters of cholesterol.