(A) Immunoblots of the indicated LRRK2-related, mitochondrial and autophagy proteins from brain lysates of LRRK2 WT, LRRK2 G2019S, and LRRK2 KO mito-QC mice treated with vehicle or GSK3357679A. (B) Quantitation of phosphorylation data from the LRRK2-related proteins displayed in A. (C) Quantitation of mitochondria- and mitochondrial biogenesis-related proteins displayed in A. (D) Quantitation of autophagy-related proteins displayed in A. Overall data is represented as mean +/- SEM. Statistical significance is displayed as *p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001.
Figure 5—source data 1. Numerical data for Figure 5.
Figure 5—source data 2. Western blot raw data files for Figure 5A.