Abstract
Objective
To evaluate the differential characteristics of SARS-COV-2 associated inflammatory multisystem syndrome (MIS-C) in children.
Methods
A retrospective cohort study was conducted. The definition of MIS-C was based on WHO criteria. Temporally related COVID-19 patients were included as controls.
Results
25 patients with MIS-C and 75 controls were included. Multivariate multiple logistic regression model of variables that showed to be significant in univariate analysis revealed that age ≥2 years (OR 24.7; 95% CI 1.03–592.4; P=0.048), lymphopenia (OR 9.03, 95%CI 2.05–39.7; P=0.004), and platelet count <150×109/L (OR 11.7; 95% CI 1.88–75.22; P=0.009) were significantly associated with MIS-C. Presence of underlying disease seemed to reduce the risk of MIS-C (OR 0.06; 95% CI 0.01–0.3).
Conclusion
MIS-C was more common in patients older than 2 years and in those with lymphopenia or thrombocytopenia. Underlying disease appears to reduce the risk of MIS-C.
Keywords: Co-morbidity, Outcome, Lymphopenia, Thrombocytopenia
Footnotes
Ethics clearence
Hospital Juan P Garrahan; No. 1294, dated October 11, 2020.
Contributors
MTR: conceptualized the study design; analyzed and interpreted the results, and wrote the manuscript; GP, MMK, AAP, MP, CG, NB, AB: recruited patients, collected demographic and clinical data analyzed and interpreted the results; RL,RB: conceptualized the study design- analyzed and interpreted the results, and commented on and revised the manuscript. All authors approved the final version of manuscript, and are accountable for all aspects related to the study.
Funding
None
Competing interest
None stated.
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