Figure 1.

Summary of pathophysiological and management challenges relevant to critically ill patients with obesity. Some challenges are relevant across the obesity severity spectrum, whereas others may predominantly affect patients with more severe obesity (BMI > 40-50 kg/m²). Figure created with BioRender.com. DJD = degenerative joint disease; FRC = functional residual capacity; GFR = glomerular filtration rate; IAP = intraabdominal pressure; LVH = left ventricular hypertrophy; PEEP = positive end-expiratory pressure; RV = right ventricle; t_1/2 = half-life; V_d = volume of distribution.