Figure 1.

Pulmonary circulation-mediated targeted therapy of heart failure by inhalation of bioactive nanotherapies. (A) Schematic illustration of in vivo targeting of the injured myocardium via inhalation of a nanotherapy TPCD NP. (B) A sketch showing preparation of a bioactive nanotherapy by nanoprecipitation/self-assembly. (C-E) Typical TEM (C) and SEM (D) images as well as size distribution (E) of TPCD NP. (F-H) Dose-dependent elimination of H₂O₂ (F) and superoxide anion (G) as well as time- and dose-dependent scavenging of DPPH radical (H) by TPCD NP. Scale bars in (C-D): 200 nm. Data in (F-H) are mean ± SD (n = 3).