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Intranasal administration of hMSC-EVs significantly decreases amyloid plaques in the HPC of 5XFAD mice. (A) Representative staining of brains with thioflavin S (ThioS), NeuN, and DAPI. Scale bar = 1 mm. (B) 20 one mm2 images were taken from the HPC of 4 different mice and plaque density was quantified using ImageJ. ****P < 0.0001.
