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. 2021 Jul 12;224(4):741–745. doi: 10.1093/infdis/jiab198

Corrigendum to: SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing

Jennifer A Rathe 1,2, Emily A Hemann 1, Julie Eggenberger 1, Zhaoqi Li 3, Megan L Knoll 1, Caleb Stokes 1,2, Tien-Ying Hsiang 1, Jason Netland 1, Kennidy K Takehara 1, Marion Pepper 1, Michael Gale Jr 1
PMCID: PMC8344695  PMID: 34250540

In “SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing” by Rathe et al. [J Infect Dis 2020; jiaa797], the advance online publication contained an error in Table 1, Figure 4B, and Figure 5 in which “sensitivity” and “specificity” labels were accidentally interchanged. The error was introduced when the labels were transferred from statistics software output to a master data file. The statistics remain the same and are correct. The corrected table and figures are provided below, and are correct in the printed version. The authors regret the error.

Original Table 1:

Specificity, % (95% CI) Sensitivity, % (95% CI) PPV, % (95% CI) NPV, % (95% CI)
RBD IgG 87 (62–98) 100 (89–100) 100 (77–100) 94 (80–99)
RBD IgM 73 (48–89) 97 (83–100) 92 (65–100) 88 (73–95)
Spike IgG 67 (42–85) 97 (83–100) 91 (62–100) 85 (70–94)
Spike IgM 60 (36–80) 97 (83–100) 90 (60–100) 83 (67–92)
Spike IgG1 71 (45–88) 100 (87–100) 100 (72–100) 88 (73–95)
Spike IgG3 93 (70–100) 97 (83–100) 93 (70–100) 97 (83–100)
Spike IgA 67 (42–85) 100 (89–100) 100 (72–100) 86 (71–94)
NP IgG 93 (70–100) 97 (83–100) 93 (70–100) 97 (83–100)

Abbreviations: CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; NP, nucleocapsid protein; NPV, negative predictive value; PPV, positive predictive value; RBD, receptor binding domain.

Corrected Table 1:

Platforms Sensitivity, % (95% CI) Specificity, % (95% CI) PPV, % (95% CI) NPV, % (95% CI)
RBD IgG 87 (62–98) 100 (89–100) 100 (77–100) 94 (80–99)
RBD IgM 73 (48–89) 97 (83–100) 92 (65–100) 88 (73–95)
Spike IgG 67 (42–85) 97 (83–100) 91 (62–100) 85 (70–94)
Spike IgM 60 (36–80) 97 (83–100) 90 (60–100) 83 (67–92)
Spike IgG1 71 (45–88) 100 (87–100) 100 (72–100) 88 (73–95)
Spike IgG3 93 (70–100) 97 (83–100) 93 (70–100) 97 (83–100)
Spike IgA 67 (42–85) 100 (89–100) 100 (72–100) 86 (71–94)
NP IgG 93 (70–100) 97 (83–100) 93 (70–100) 97 (83–100)

Abbreviations: CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; NP, nucleocapsid protein; NPV, negative predictive value; PPV, positive predictive value; RBD, receptor binding domain.

Original Figure 4:

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Corrected Figure 4:

graphic file with name jiab198f0002.jpg

Original Figure 5:

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Corrected Figure 5:

graphic file with name jiab198f0004.jpg


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