In “SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing” by Rathe et al. [J Infect Dis 2020; jiaa797], the advance online publication contained an error in Table 1, Figure 4B, and Figure 5 in which “sensitivity” and “specificity” labels were accidentally interchanged. The error was introduced when the labels were transferred from statistics software output to a master data file. The statistics remain the same and are correct. The corrected table and figures are provided below, and are correct in the printed version. The authors regret the error.
Original Table 1:
Specificity, % (95% CI) | Sensitivity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | |
---|---|---|---|---|
RBD IgG | 87 (62–98) | 100 (89–100) | 100 (77–100) | 94 (80–99) |
RBD IgM | 73 (48–89) | 97 (83–100) | 92 (65–100) | 88 (73–95) |
Spike IgG | 67 (42–85) | 97 (83–100) | 91 (62–100) | 85 (70–94) |
Spike IgM | 60 (36–80) | 97 (83–100) | 90 (60–100) | 83 (67–92) |
Spike IgG1 | 71 (45–88) | 100 (87–100) | 100 (72–100) | 88 (73–95) |
Spike IgG3 | 93 (70–100) | 97 (83–100) | 93 (70–100) | 97 (83–100) |
Spike IgA | 67 (42–85) | 100 (89–100) | 100 (72–100) | 86 (71–94) |
NP IgG | 93 (70–100) | 97 (83–100) | 93 (70–100) | 97 (83–100) |
Abbreviations: CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; NP, nucleocapsid protein; NPV, negative predictive value; PPV, positive predictive value; RBD, receptor binding domain.
Corrected Table 1:
Platforms | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) |
---|---|---|---|---|
RBD IgG | 87 (62–98) | 100 (89–100) | 100 (77–100) | 94 (80–99) |
RBD IgM | 73 (48–89) | 97 (83–100) | 92 (65–100) | 88 (73–95) |
Spike IgG | 67 (42–85) | 97 (83–100) | 91 (62–100) | 85 (70–94) |
Spike IgM | 60 (36–80) | 97 (83–100) | 90 (60–100) | 83 (67–92) |
Spike IgG1 | 71 (45–88) | 100 (87–100) | 100 (72–100) | 88 (73–95) |
Spike IgG3 | 93 (70–100) | 97 (83–100) | 93 (70–100) | 97 (83–100) |
Spike IgA | 67 (42–85) | 100 (89–100) | 100 (72–100) | 86 (71–94) |
NP IgG | 93 (70–100) | 97 (83–100) | 93 (70–100) | 97 (83–100) |
Abbreviations: CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; NP, nucleocapsid protein; NPV, negative predictive value; PPV, positive predictive value; RBD, receptor binding domain.
Original Figure 4:
Corrected Figure 4:
Original Figure 5:
Corrected Figure 5: