Table 2:
Symptoms after each vaccine dose
| Symptoms | Full Cohort: | After 1st dose | After 2nd dose | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 1st dose | 2nd dose | P-valuea | BNT162b2 | mRNA-1237 | p-valueb | BNT162b2 | mRNA-1237 | p-valueb | |
| n=48 | n=27 | n=21 | n=27 | n=21 | |||||
| Injection site symptoms, % (n) | |||||||||
| Any injection site symptoms | 88% (42) | 88% (42) | >0.99 | 78% (21) | 100% (21) | 0.02 | 78% (21) | 100% (21) | .02 |
| Pain | 88% (42) | 85% (41) | 0.71 | 78% (21) | 100% (21) | 0.02 | 78% (21) | 95% (20) | 0.12 |
| Redness | 4% (2) | 10% (5) | 0.08 | 0% (0) | 10% (2) | 0.19 | 4% (1) | 19% (4) | 0.15 |
| Swelling | 17% (8) | 17% (8) | >0.99 | 7% (2) | 29% (6) | 0.12 | 11% (3) | 24% (5) | 0.27 |
| Itching | 4% (2) | 4% (2) | >0.99 | 4% (1) | 5% (1) | >.99 | 4% (1) | 5% (1) | >.99 |
| Rash around injection site | 2% (1) | 4% (2) | 0.32 | 0% (0) | 5% (1) | 0.44 | 0% (0) | 10% (2) | 0.19 |
| Generalized symptoms, % (n) | |||||||||
| Any general symptoms | 48% (23) | 92% (44) | <0.001 | 44% (12) | 52% (11) | 0.77 | 85% (23) | 100% (21) | 0.12 |
| Fever | 12% (6) | 62% (30) | <0.001 | 19% (5) | 5% (1) | 0.21 | 52% (14) | 76% (16) | 0.13 |
| Chills | 8% (4) | 48% (23) | <0.001 | 11% (3) | 5% (1) | 0.62 | 37% (10) | 62% (13) | 0.14 |
| Headache | 21% (10) | 67% (32) | <0.001 | 11% (3) | 33% (7) | 0.08 | 56% (15) | 81% (17) | 0.07 |
| Joint pain | 8% (4) | 31% (15) | 0.002 | 7% (2) | 10% (2) | >0.99 | 30% (8) | 33% (7) | >0.99 |
| Muscle/body aches | 21% (10) | 69% (33) | <0.001 | 30% (8) | 10% (2) | 0.15 | 59% (16) | 81% (17) | 0.13 |
| Fatigue or tiredness | 44% (21) | 81% (39) | <0.001 | 41% (11) | 48% (10) | 0.77 | 67% (18) | 100% (21) | 0.003 |
| Nausea | 4% (2) | 12% (6) | 0.10 | 4% (1) | 5% (1) | >0.99 | 7% (2) | 19% (4) | 0.38 |
| Vomiting | 0% (0) | 0% (0) | --- | 0% (0) | 0% (0) | --- | 0% (0) | 0% (0) | --- |
| Diarrhea | 4% (2) | 4% (2) | >0.99 | 4% (1) | 5% (1) | >0.99 | 0% (0) | 10% (2) | 0.19 |
| Abdominal pain | 2% (1) | 0% (0) | 0.32 | 0% (0) | 5% (1) | 0.44 | 0% (0) | 0% (0) | --- |
| Rash not near injection site | 0% (0) | 0% (0) | --- | 0% (0) | 0% (0) | --- | 0% (0) | 0% (0) | --- |
| Lump/swelling in breast (same side as injection) | 0% (0) | 2% (1) | 0.32 | 0% (0) | 0% (0) | --- | 4% (1) | 0% (0) | >0.99 |
| Lump/swelling in breast (opposite side as injection) | 0% (0) | 0% (0) | --- | 0% (0) | 0% (0) | --- | 0% (0) | 0% (0) | --- |
| Mastitis | 2% (1) | 0% (0) | 0.32 | 0% (0) | 5% (1) | 0.44 | 0% (0) | 0% (0) | --- |
| Decrease in milk supply | 2% (1) | 2% (1) | >0.99 | 0% (0) | 5% (1) | 0.44 | 0% (0) | 5% (1) | 0.44 |
a
McNemar’s test;
b
Fisher’s Exact test