Table 2. Drug resistance-related SNPs genotyped by GenRe-Mekong (excludes kelch13).
| Chromosome | Position | Gene Id | Gene Description | Mutation | Reference | Alternate |
|---|---|---|---|---|---|---|
| Pf3D7_04_v3 | 748239 | PF3D7_0417200 |
dhfr (bifunctional dihydrofolate reductase-thymidylate synthase) |
N51I | A | T |
| Pf3D7_04_v3 | 748262 | C59R/Y | T | C | ||
| Pf3D7_04_v3 | 748263 | C59R/Y | G | A | ||
| Pf3D7_04_v3 | 748410 | S108N/T | G | AC | ||
| Pf3D7_04_v3 | 748577 | I164L | A | T | ||
| Pf3D7_05_v3 | 958145 | PF3D7_052300 |
mdr1 (multidrug resistance protein 1) |
N86Y | A | T |
| Pf3D7_05_v3 | 958440 | Y184F | A | T | ||
| Pf3D7_05_v3 | 961625 | D1246Y | G | T | ||
| Pf3D7_07_v3 | 403623 | PF3D7_0709000 |
crt (chloroquine resistance transporter) |
N75D/E | T | A |
| Pf3D7_07_v3 | 403625 | K76T | A | C | ||
| Pf3D7_07_v3 | 405362 | N326S | A | G | ||
| Pf3D7_07_v3 | 405600 | I356T | T | C | ||
| Pf3D7_08_v3 | 549681 | PF3D7_0810800 |
dhps (dihydropteroate synthetase) |
S436A/Y/F/G | T | GC |
| Pf3D7_08_v3 | 549682 | S436A/Y/F/G | C | TAG | ||
| Pf3D7_08_v3 | 549685 | A437G | G | C | ||
| Pf3D7_08_v3 | 549993 | K540E/N | A | GT | ||
| Pf3D7_08_v3 | 549995 | K540E/N | A | TG | ||
| Pf3D7_08_v3 | 550117 | A581G | C | G | ||
| Pf3D7_08_v3 | 550212 | A613S/T | G | TA | ||
| Pf3D7_13_v3 | 748395 | PF3D7_1318100 | fd (ferredoxin) | D193Y | C | A |
| Pf3D7_13_v3 | 2504560 | PF3D7_1362500 | exo (exonuclease) | E415G | A | G |
| Pf3D7_14_v3 | - | PF3D7_1408000 and PF3D7_1408100 | pm23 (plasmepsin 2 and plasmepsin 3) | Breakpoint | - | - |
| Pf3D7_14_v3 | 1956225 | PF3D7_1447900 |
mdr2 (multidrug resistance protein 2) |
T484I | G | A |
| Pf3D7_14_v3 | 2481070 | PF3D7_1460900 |
arps10 (apicoplast ribosomal protein S10) |
V127M | G | A |
| Pf3D7_14_v3 | 2481073 | D128Y/H | G | TC |