Figure 2.

Social behavior results at PND21. A, Frequency of interacting with stranger 1 in T2. B, Time spent interacting with stranger 1 in T2. C, Frequency of grooming in T2. D, Time spent grooming in T2. E, Frequency of interacting with stranger 1 in T3. F, Time spent interacting with stranger 1 in T3. G, Frequency of interacting with stranger 2 in T3. H, Time spent interacting with stranger 2 in T3. I, Frequency of grooming in T3. J, Time spent grooming in T3. The F test was used for data analysis. Treatment, sex, and treatment by sex interaction were included in the model. Treatment effects were analyzed with dam nested under treatment and used as error term. There was significant (p < 0.05) interaction between treatment and sex in frequency and time spent in grooming in T3. Significant differences are indicated in the figures. Error bars represent SEM. Number of replicates tested = 13 female and 13 male mice for CTL group, 10 female and 10 male mice for OXY group. Datapoints for all replicates who engaged in the various behaviors are shown. For grooming in T2, many of the animals in both groups did not exhibit this behavior.