Fig. 1.
Meta-analysis pipeline for gene prioritization and associated pathway analysis. a) Workflow used to obtain prognostic markers and therapeutic targets from proteomics and transcriptomics datasets. b) Triangular heatmap showing pairwise overlaps between transcriptomic and proteomic datasets. The number within each box denotes the number of genes that showed up between the corresponding intersections. The colour of a box denotes the significance of overlap determined by Fisher's exact test. c) Gene ontology of all genes (566) in the significant intersections obtained during the overlap analysis plotted with the number of genes in each term on the X-axis, proportion of genes enriched compared to the total number of genes in each term as the size of dots and the colour representing log10 p-adj value (q-value) of enrichment (calculated by a hypergeometric test with Benjamini-Hochberg correction). d) Venn diagram showing the number of genes that are induced by Type I, II, or III interferons. The analysis was performed on Interferome v2.01 using the union of significant intersections (566).