Figure 6.

Behavioral alterations in Pcdh19 KO males and their WT littermates. A, Schematic of the behavioral experiments conducted. B, Total distance traveled by males during the 20 min of the open field test at P21. C, Distance traveled in the open field test by P21 males in the first 5 min interval of the open field test. Open field test results correspond to the second day of testing in A and B. D, Total time spent by males in the open arms of the elevated plus maze during the 5 min test at P60. E, Time spent by P21 males interacting with a nonfamiliar female in estrus. The total duration of the test was 5 min. B–D, The top axis shows the raw data points for each group. To their right, the gap in the line indicates the mean, and the lines extending vertically represent the SD. The group and group sizes are indicated at the bottom. Note that each group appears twice in every graph, but with two different colors. The mean difference for each comparison is plotted in the lower axis as a bootstrap sampling distribution. The black dot represents the mean, and the vertical bar its 95% confidence interval. At the top of each graph the significance scores of the one-way ANOVA or Kruskal–Wallis test and their post hoc test are indicated. *p < 0.05; **p < 0.01. Test results with male animals that did not reach significance are presented in Extended Data Figure 6-1.