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. 1978 Jun 1;19(2):285–297. doi: 10.1186/BF03547633

Combined Therapeutic Effect of Dietary Selenium and Vitamin Ε on Manifested Vesd Syndrome in Weaned Pigs

Kombinerad terapeutisk effekt av dietärt selen och vitamin E på manifesterai vitamin E- och selenbrist (VESD)-syndrom hos avvanda grisar

Juhani Hakkarainen 113,213,✉, Paul Lindberg 113,213, Gösta Bengtsson 113,213, Lennart Jönsson 113,213
PMCID: PMC8366339  PMID: 696540

Abstract

By using a therapeutic dietary supplementation in pigs, which had developed the vitamin Ε and selenium deficiency (VESD) syndrome, the same amounts of α-tocopheryl acetate and selenium were found to be effective as under prophylactic conditions. The experiment thus supported the conclusions that the addition of 5 mg DL-α-tocopheryl acetate/kg and 135 μg selenium/kg to a diet, which contained only traces of vitamin Ε and selenium, represents a level of minimal requirement. Glutathione peroxidase activity in blood serum was used to evaluate the selenium status in pigs. A modified method for determination of tocopherol in fat tissue was described. The addition of 15 mg α-tocopheryl acetate/kg diet was demonstrated to be sufficient to maintain the tocopherol stores in body fat at an unchanged level.

Keywords: dietary tocopherol, selenium, therapy, pigs, serum glutathione peroxidase, tissue fat tocopherol

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Acknowledgment

We are indebted to Mrs. Ann-Margret Beskow, to Mrs. Eva Kikas and to Mr. Filip Carlson for their excellent technical assistance.

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