FIGURE 1.

Development of ACR symptoms common to LEW→BN and DA→LEW rat OLT models. OLT rat recipients in alloimmune strain combinations that present ACR typically show lethargy and loss of appetite by POD3, and symptoms progressively worsen to development of severe jaundice and ascites from POD5. At the cellular level, assessment of RAI shows mononuclear cell infiltration as early as POD1, which continues to expand to liver parenchyma, with indication of severe ACR at POD7. LEW→BN rat OLT recipients typically survive for an average MST of 13.66 d, while DA→LEW models survive on average 11.22 d. ACR, acute cellular rejection; BN, Brown Norway; DA, Dark Agouti; IRI, ischemia-reperfusion injury; LEW, Lewis; MST, median survival time; OLT, orthotopic liver transplantation; POD, postoperative day; RAI, Rejection Activity Index.