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. 2021 Jul 3;40(33):5168–5181. doi: 10.1038/s41388-021-01916-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — In CRC cells, hypoxia induces FTO degradation through the ubiquitination-proteasomal pathway. Downregulation of FTO increases MTA1 mRNA m⁶A methylation, which is recognized by the m⁶A “reader” IGF2BP2, maintaining \ RNA stability and protein expression, thus leading to acceleration of cancer metastasis and progression.