Abstract
The antioxydants butylhydroxyanisol (BHA), butylhydroxytoluene (BHT) and ethoxyquin (EMQ) were tested for mutagenicity in the so-called “Ames test”. The test was performed with and without the addition of microsomal mixed function oxidase system from rat liver. The compounds were found not to be mutagenic in this test. At high concentration of BHA and EMQ toxic effects on the growth of the bacteria were observed.
Keywords: mutagenicity, Ames test, feed additives, anti-oxydants
Sammendrag
Antioksydantene butylhydroksytoluen (BHT), butylhydroksyanisol (BHA) og ethoxyquin (EMQ) er undersøkt med hensyn til muta- genisitet i den såkalte “Ames test” med negativt resultat. Undersøkel- sen har vært utført både med og uten tilsetning av mikrosomalt blan- det oksydase system fra rottelever fra dyr indusert med PGB. Ved høye konsentrasjoner av butylhydroksyanisol og ethoxyquin kan man ob- servere toksisk virkning på bakterienes vekst.
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Acknowledgments
The excellent technical assistance of Randi Hag in gratefully acknowledged.
References
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