At the request of the corresponding author and investigator at the University of California, San Francisco, and in consultation with Molecular Pharmacology, this paper has been retracted. It was found there was improper manipulation, reuse, and analyses represented by Figs. 1A, 3A, 4A, 4C, 5, and 7.
. 2021 Aug;100(2):82. doi: 10.1124/mol.109.056002retraction
Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2α (eIF2α)-kinase (PERK) and general control nonderepressible-2 eIF2α kinase (GCN2), and global translational shutoff. Mol Pharmacol 76(3):503–515; DOI: https://doi.org/10.1124/mol.109.056002.
Received 2021 May 20; Accepted 2021 May 20; Issue date 2021 Aug.
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics
PMCID: PMC8382260 PMID: 34404737
This retracts the article "Hepatic CYP3A Suppression by High Concentrations of Proteasomal
Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction,
Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation
Factor 2α (eIF2α)-Kinase (PERK) and General Control
Nonderepressible-2 eIF2α Kinase (GCN2), and Global Translational
Shutoff" in volume 76 on page 503.