Abstract
Twenty-seven weaned pigs with a wasting appearance were investigated. From a morphological point of view the pigs were divided into three groups. In the group of pigs with macro-scopical signs of regional ileitis, affected tissue showed substantial epithelial proliferation, and electron microscopic studies revealed the presence of microorganisms within the cytoplasm of the epithelial cells. There was a loss of, or only faint, enzymatic activity of alkaline phosphatase in the mucosal epithelium. In another group of five pigs there was no, or only slight, light microscopical signs of regional ileitis but presence of intracellular microorganisms. The enzymatic activity of the ileal epithelium was low. Low enzymatic activity of the ileal epithelium was observed in a third group of wasting pigs, which had no histological or electron microscopical signs of regional ileitis.
Keywords: pigs, regional ileitis, wasting syndrome, alkaline phosphatase, intracellular microorganisms
Sammanfattning
Författarna har undersökt 27 grisar med typiskt “pelle”-utseende. Ur morfologisk synpunkt indelades de i tre grupper. I gruppen med makroskopiskt påvisbar regional ileit sågs adenomatösa slemhinneproliferationer. Vid elektronmikroskopisk undersökning avslöjades intracytoplasmatiska mikroorganismer i epithelcellerna. Aktiviteten av alkaliskt fosfatas var låg eller saknades helt i slemhinneepithelet. I andra gruppen förekom intracellulär mikroorganismer men endast svaga histologiska tecken på regional ileit. Enzymaktiviteten i epithelcellerna var låg, liksom i tredje gruppen. I sistnämnda grupp förelåg varken ljusmikroskopiska eller elektronmikroskopiska förändringar tydande på regional ileit. Ur patogenetisk synpunkt diskuteras två faktorer som förknippas med sjukdomens uppkomstmekanism. Den ena är predisponerande gastrointestinal rubbning, den andra är intracellulär förekomst av mikroorganismer.
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