FIG 7.
Our 3D in vitro TB granuloma structures show similar structural and cellular composition based on (a) immunofluorescence staining with antibodies for CD3+ T cells (blue, V450) and alveolar macrophages (red, PE-CF594) to (b) published in vivo TB lung granulomas of nonhuman primates, stained with antibodies for CD3+ T cells (red) and CD68+ macrophages (green), surrounding the necrotic center (unstained). Adapted from Flynn et al. 2015 with permission (license number: 4967651365284) (19).