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. 2021 Aug 6;8(4):ENEURO.0069-21.2021. doi: 10.1523/ENEURO.0069-21.2021

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Copyright © 2021 Huang and Park

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — The released Nluc-GPC4 includes the heparan sulfate side chain. A, Heparinase II and III treatment of media Nluc-GPC4 reduced the binding of GPC4 to DEAE anion exchange column, by removing the negatively charged heparan sulfate side chains (one-sample t test p = 0.0365, Cohen’s d = 3.482). B, The surface Nluc-GPC4 released by PI-PLC showed similar binding to DEAE as basal release GPC4, indicating that both lipase and protease release mechanisms contain the heparan sulfate modification and are capable of known synaptogenic signaling functions (t test p = 0.9467, Cohen’s d = 0.390); *p < 0.05, ns: not significant.