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. 2021 Jul 28;9(8):904. doi: 10.3390/biomedicines9080904

Figure 3.

Figure 3

Leptin levels and inflammatory status in pericoronary fat patients. (A) Leptin and (B) 3-nitrotyrosine level in pericoronary fat specimens from 150 normal glucose, 150 prediabetic patients, and 55 prediabetic current-metformin-users assessed by enzyme-linked immunosorbent assay (ELISA) assay on homogenates. Boxplots represent the median, 25th, and 75th percentiles values, while the black symbols outside represent the 10th and 90th percentiles. (C) Assessment of cytokine levels in pericoronary fat specimens from 150 normal glucose, 150 prediabetic patients, and 55 prediabetic current-metformin-users assessed by the ELISA assay on homogenates. TNFα: tumor necrosis alpha; IL-6: interleukin 6; IL-1β: interleukin 1 beta; MCP-1: monocyte chemoattractant protein 1. For comparison between the cohorts, we used the ANOVA test. * p < 0.05 vs. normal glucose patients; ‡ p < 0.05 vs. prediabetic patients without metformin.