Table 5.
Top ten GAD disease classes related with obesity.
| miRNA Name | GAD Disease Classes | No. of Database-Matched Genes | No. of Disease Class-Related Targets (%) | p-Value |
|---|---|---|---|---|
| miR-328-3p | METABOLIC | 15,209 | 4014 (26.4) | <0.0001 |
| CARDIOVASCULAR | 15,209 | 3286 (21.6) | <0.0001 | |
| CHEMDEPENDENCY | 15,209 | 2919 (19.2) | <0.0001 | |
| NEUROLOGICAL | 15,209 | 2218 (14.6) | 0.0003 | |
| PHARMACOGENOMIC | 15,209 | 2178 (14.3) | <0.0001 | |
| PSYCH | 15,209 | 1573 (10.3) | <0.0001 | |
| UNKNOWN | 15,209 | 1253 (8.2) | 0.0004 | |
| OTHER | 15,209 | 1242 (8.2) | 0.0002 | |
| DEVELOPMENTAL | 15,209 | 1172 (7.7) | 0.0002 | |
| HEMATOLOGICAL | 15,209 | 1169 (7.7) | 0.0191 | |
| miR-1301-3p | METABOLIC | 16,121 | 4422 (27.4) | <0.0001 |
| CARDIOVASCULAR | 16,121 | 3565 (22.1) | <0.0001 | |
| CHEMDEPENDENCY | 16,121 | 3208 (19.9) | <0.0001 | |
| NEUROLOGICAL | 16,121 | 2396 (14.9) | <0.0001 | |
| PHARMACOGENOMIC | 16,121 | 2318 (14.4) | <0.0001 | |
| INFECTION | 16,121 | 1762 (10.9) | 0.0304 | |
| PSYCH | 16,121 | 1703 (10.6) | <0.0001 | |
| UNKNOWN | 16,121 | 1356 (8.4) | <0.0001 | |
| OTHER | 16,121 | 1332 (8.3) | 0.0003 | |
| DEVELOPMENTAL | 16,121 | 1290 (8.0) | <0.0001 | |
| miR-4685-3p | METABOLIC | 13,811 | 3686 (26.7) | 0.0001 |
| CARDIOVASCULAR | 13,811 | 3017 (21.8) | <0.0001 | |
| CHEMDEPENDENCY | 13,811 | 2752 (19.9) | <0.0001 | |
| NEUROLOGICAL | 13,811 | 2051 (14.9) | 0.0002 | |
| PHARMACOGENOMIC | 13,811 | 2006 (14.5) | <0.0001 | |
| PSYCH | 13,811 | 1448 (10.5) | <0.0001 | |
| UNKNOWN | 13,811 | 1145 (8.3) | 0.0065 | |
| OTHER | 13,811 | 1129 (8.2) | 0.0113 | |
| DEVELOPMENTAL | 13,811 | 1099 (8.0) | <0.0001 | |
| HEMATOLOGICAL | 13,811 | 1088 (7.9) | 0.0046 | |
| miR-6803-3p | METABOLIC | 17,852 | 4678 (26.2) | <0.0001 |
| CARDIOVASCULAR | 17,852 | 3773 (21.1) | <0.0001 | |
| CHEMDEPENDENCY | 17,852 | 3340 (18.7) | <0.0001 | |
| NEUROLOGICAL | 17,852 | 2546 (14.3) | 0.0069 | |
| PHARMACOGENOMIC | 17,852 | 2493 (14.0) | <0.0001 | |
| PSYCH | 17,852 | 1790 (10.0) | <0.0001 | |
| UNKNOWN | 17,852 | 1452 (8.1) | <0.0001 | |
| DEVELOPMENTAL | 17,852 | 1356 (7.6) | <0.0001 | |
| HEMATOLOGICAL | 17,852 | 1356 (7.6) | 0.0074 | |
| RENAL | 17,852 | 1288 (7.2) | <0.0001 | |
| Total | METABOLIC | 19,922 | 4959 (24.9) | <0.0001 |
| CARDIOVASCULAR | 19,922 | 4003 (20.1) | <0.0001 | |
| CHEMDEPENDENCY | 19,922 | 3524 (17.7) | <0.0001 | |
| IMMUNE | 19,922 | 2786 (14.0) | 0.0408 | |
| NEUROLOGICAL | 19,922 | 2701 (13.6) | 0.0189 | |
| PHARMACOGENOMIC | 19,922 | 2650 (13.3) | <0.0001 | |
| INFECTION | 19,922 | 2057 (10.3) | <0.0001 | |
| PSYCH | 19,922 | 1880 (9.4) | <0.0001 | |
| UNKNOWN | 19,922 | 1556 (7.8) | <0.0001 | |
| OTHER | 19,922 | 1508 (7.6) | 0.0006 |