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. 2021 Jul 29;10(8):1928. doi: 10.3390/cells10081928

Figure 4.

Figure 4

P2X7R -dependent IL-6 release. IL-6 release in (a) hPSCs and mPSCs from (b) P2X7R wt and (c) P2X7R P451L mice after treatment with different concentrations of the agonist BzATP (0, 10, 100, 1000 μM) alone and in combination with 10 μM inhibitor AZ10606120 (AZ) and A438079 (A43). Data were normalized to control values (CTR). One-sample t-test followed by Bonferroni correction was performed and significance compared to the control is indicated as follows * p < 0.05, ** p < 0.01, **** p < 0.0001.; comparisons between agonist and agonist + inhibitor have been evaluated with t-test and significance is indicated by # p < 0.05, ## p < 0.01. (b) n is reported in the graph except for AZ10606120 10 μM + BzATP 100 μM, where n = 2. For hPSCs BzATP 100 μM, uncorrected p is 0.045; P2X7R wt BzATP 1000 μM, uncorrected p is 0.057.