Table 1.

Upregulated miRNAs in pulp inflammation.

miRNA	Target Gene	MiRNA Function	Ref
miR-21	TLR-4, TRAF6, PDCD	Anti-inflammatory activity Inhibition NF-κB signal pathway	[53,54,55,56,57]
miR-146a	IRAK1, TRAF6, COX-2, 5-LO	Anti-inflammatory activity Suppressing MAPK pathway Cell proliferation and odontogenic differentiation of hDPC	[58,59,60,61,62,63,64]
miR-150	IL-6, NF-κB1, JAK2, IRAK2, c-Myb, Osteoactivin/GPNMB	Differentiation of B cells Differentiation and function of osteoblasts, and osteoclasts Regulator of inflammatory responses	[51,65,66,67,68,69,70,71,72,73,74,75,76,77]
miR-223	TLR-3, TLR-4, IKK-α, MKP-5	Granulopoiesis and monocyte activation Cell differentiation Pro-inflammatory Pulpitis repair	[78,79,80,81,82,83,84,85,86,87,88,89]
miR-506	SIRT1	Cell differentiation and proliferation Activating the immune system Pro-inflammatory	[90,91,92,93,94]
miR-584	MAPK8	Suppress cell proliferation, migration, and invasion Pulp tissue homeostasis Favoring the inflammatory response	[51,95,96,97,98,99,100]
miR-766	HSF1	Inflammatory gene suppressor Temperature stress response	[51,52,101]