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. 2021 Aug 18;11(8):1231. doi: 10.3390/biom11081231

Figure 1.

Figure 1

(a) The number (nr) of papers on experimental animals, published each year since 1970 and up to 2020, containing the terms “metformin”, “cancer”, and “metformin and cancer”. (b) The same data displayed as the ratio between the nr of papers published in each year divided by the corresponding feature in 2019. The steep increase in experimental studies dealing with metformin was associated with the interest in the anticancer potential of this drug.