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Suggested model of compartmentalization of the cAMP signal in endothelial cells of the cerebral microvasculature and its participation in the integrity of the barrier function. AC: adenylyl cyclase; AKAP: A-kinase anchor proteins; GPCR: G-protein coupled receptor; PDE: phosphodiesterase; PKA: protein kinase A; sAC: soluble adenylyl cyclase; TJ: Tight junction. For more details, see text.
