Table 2.
KEGG and Reactome pathway analysis of differentially expressed genes. KEGG and Reactome pathway enrichment analyses were carried out with the genes downregulated in gip2-silenced SKOV3 cells using STRING and Cytoscape applications. Major pathways of the PPI identified in downregulated and upregulated genes along with the gene count and false discovery rate are presented.
| Pathway | Term | Description | Gene Count | False Discovery Rate |
|---|---|---|---|---|
| KEGG Pathway |
hsa01100 | Metabolic pathways | 36 | 5.40e−08 |
| hsa00190 | Oxidative phosphorylation | 24 | 6.13e−21 | |
| hsa05200 | Pathways in cancer | 21 | 5.83e−07 | |
| hsa01524 | Platinum drug resistance | 11 | 5.45e−09 | |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 9 | 1.75e−06 | |
| Reactome Pathway |
HSA-1428517 | TCA Cycle and Respiratory electron transport | 21 | 7.61e−16 |
| HSA-109581 | Apoptosis | 14 | 1.62e−08 | |
| HSA-109582 | Hemostasis | 14 | 1.67e−02 | |
| HSA-1268020 | Mitochondrial protein import | 4 | 2.76e−02 | |
| HSA-1059683 | Interleukin-6 signaling | 2 | 3.69e−02 |