Figure 4.

Platelet BMP-4 modulates expression and secretion of P-selectin, RANTES and PF-4. (A) Time-dependent release of P-selectin from platelets of control (BMP4^Plt+/+) or BMP4^Plt−/−mice after treatment with TNFα (10 ng/g body weight). n = 5 per group. (B) mRNA expression of P-selectin in the carotid artery from control or BMP4^Plt−/−/LDLr^−/− mice after guide wire injury. n = 5 per group. (C,D) Plasma level of RANTES and PF-4 in control littermates or BMP4^Plt−/−/LDLr^−/− mice after carotid wire injury. Plasma from 3 mice were pooled for each group. (E,F) mRNA expression of RANTES and PF-4 in the carotid artery of control littermates or BMP4^Plt−/−/LDLr^−/− mice seven days after guide wire injury. n = 8 per group. * p ≤ 0.05; ** p ≤ 0.01; n.s., not significant.