Table 2.
Multiple HCMV-encoded proteins usurp the innate immune response.
| Herpesvirus | Viral Protein | Host Cell Target |
|---|---|---|
| HCMV | pp65 | interacts with & blocks IFI16 signaling |
| interacts with & blocks STING signaling | ||
| binds & inactivates cGAS | ||
| pUL94 | interacts with & blocks STING signaling | |
| pp71 | interacts with & blocks STING signaling | |
| pUL26 | suppresses accumulation of ISGylated proteins via ISG15 interaction | |
| IE1 | attenuates ISG15 expression | |
| pUL50 | inhibits global ISGylation | |
| pUL23 | interacts with NMI, restricting ISG transcription via STAT1 | |
| targets STING for degradation | ||
| IE2 | binds NFκB, abrogating its binding to the IFNβ promoter | |
| UL37x1/vMIA | suppresses MAVS signaling | |
| degrades RIG-I | ||
| pUS9 | interacts with STING, blocking IRF3 activity | |
| targets MAVS, preventing TBK1 & IRF3 recruitment | ||
| pUL42 | interacts with cGAS, blocking cGAMP production | |
| interacts with and retains STING in the ER, preventing its activation | ||
| pUL31 | interacts with cGAS, blocking cGAMP production | |
| IRS1, TRS1 | target OAS/Rnase L signaling | |
| pORF94 | inhibits OAS1 expression and function |