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. 1975 Mar 1;16(1):126–133. doi: 10.1186/BF03546701

Studies on Pentagastrin-Induced Hypocalcaemia in Lactating Cows

Studier över pentagastrininducerad hypokalcemi hos lakterande kor

J Luthman 1,✉, J Persson 1, S O Jacobsson 1
PMCID: PMC8396012  PMID: 1136900

Abstract

During recent years it has been evident that a number of gastrointestinal hormones are potent calcitonin secretagogues, and it has been suggested that a gastrointestinal-thyroid C cell system exists as a part of post prandial calcium homeostasis. In the present study the hypocalcaemic effect of pentagastrin, a synthetic peptide with gastrin effects, was studied in lactating cows. Intravenous infusion of pentagastrin caused marked hypocalcaemia and hypophosphataemia in the cows. Thyroidectomy completely abolished the hypocalcaemic and hypophosphataemic effects of the peptide. The results thus suggested that the effects of the peptide were due to release of endogenous calcitonin.

Keywords: cow, hypocalcaemia, hypophosphataemia, pentagastrin, thyroidectomy

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