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Experimental setup. Analysis of acute (A) and chronic (B) toxicity of liposomal formulations F and L in healthy C57Bl/6 mice. Note that 1 therapeutic dose (TD) corresponds to 1.5 nmol/g and 5 TD corresponds to 7.5 nmol/g. Analysis of antitumor effects of combination therapy in KB-8-5 tumor-bearing SCID mice (C). Combination therapy comprised polychemotherapy (PCHT) with doxorubicin, vincristine, and cyclophosphamide, alongside injection of siMDR/F lipoplexes.
