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. 2021 Jul 27;13(8):1152. doi: 10.3390/pharmaceutics13081152

Figure 10.

Figure 10

Comparison of the action of ion release from MBG-75S on CD206 expression in RAW 264.7 macrophages in monoculture (RAW MBG T) and in coculture with EPCs (RAW EPC MBG T). For the coculture, RAW 264.7 macrophages were seeded on glass coverslips introduced into 6-well culture plates and EPCs were seeded around each coverslip. Additionally, 1 mg/mL of MBG-75S was deposited on transwell inserts, allowing the ions to diffuse through the pores in both monocultures and cocultures. CD206 expression was evaluated as specific marker of M2 phenotype after 7 days of culture. Cocultures of RAW 264.7 macrophages with EPCs in the absence of material (RAW EPC) and cocultures of RAW M2d macrophages with EPCs in the absence of material (RAW M2d EPC) were carried out in parallel. Statistical significance: *** p < 0.005 (comparison with RAW MBG T); ### p < 0.005, ## p < 0.01 (comparison with RAW EPC); & p < 0.05 (comparison with RAW M2d EPC).