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. 2021 Aug 12;13(8):1246. doi: 10.3390/pharmaceutics13081246

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The investigation of the pH on the uptake of [¹⁸F]-D4-FCH. (A) The intracellular pH (pH_in) and extracellular pH (pH_e) were assessed in the cells following the treatment with 200 µM CoCl₂ for 24 h. (B) Following a 24 h incubation under normoxic conditions, PC-3 and MDA-MB-231 cells were incubated with 0.37 MBq [¹⁸F]-D4-FCH in pH-adjusted uptake media (pH_e between 6.0 and 8.0) without CO₂ buffering for 1 h. The data presented are the mean ± standard deviation. One-way ANOVA with post-hoc Tukey’s multiple comparison tests were carried out.