Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 27;13(8):1146. doi: 10.3390/pharmaceutics13081146

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Comparison between the apparent permeability measured with the standard and the modified MDCK-MDR1 assay for a chemical series (N = 39). The standard permeability assay was performed as described in Section 2.3. The modified permeability assay with prolonged preincubation time is described above. All P_app values represent mean values of duplicates. P_{app,Intrinsic} ratio is calculated by dividing P_{app,Intrinsic} from the modified assay by P_{app,Intrinsic} from the standard assay. (A) P_{app,Intrinsic} values from the modified assay were plotted against P_{app,Intrinsic} values from the standard assay. Solid line shows 1:1 correlation. (B) Ratios between P_{app,Intrinsic} values from standard and modified assays were plotted against cLogP.