Table 3.
Ex vivo susceptibility geometric mean to chloroquine, quinine, lumefantrine, desethylamodiaquine, pyronaridine, and piperaquine according to the pfcoronin genotype (P76 or 76S).
| Drug (Isolates No) | Isolates Wild-Type (P76) | Isolates with 76S Mutation |
p-Value (t-Test) |
||
|---|---|---|---|---|---|
| IC50 Geometric Mean (nM) | Min-Max IC50 | IC50 Geometric Mean (nM) | Min-Max IC50 | ||
| Chloroquine (328) | 84.0 | 2.8–764.7 | 95.2 | 8.0–350.9 | 0.463 |
| Quinine (325) | 281.0 | 6.2–757.2 | 268.7 | 23.3–664.7 | 0.617 |
| Lumefantrine (329) | 6.7 | 0.4–68.8 | 6.5 | 0.5–46.0 | 0.878 |
| Desethylamodiaquine (306) | 40.7 | 0.6–775.9 | 34.3 | 2.0–152.5 | 0.343 |
| Mefloquine (321) | 22.9 | 0.7–98.0 | 26.1 | 3.2–87.8 | 0.295 |
| Pyronaridine (319) | 14.0 | 0.2–119.3 | 12.6 | 1.0–56.9 | 0.410 |
| Piperaquine (321) | 25.1 | 5.5–67.1 | 25.2 | 0.7–379.3 | 0.983 |