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. 1974 Jun 1;15(2):188–197. doi: 10.1186/BF03547480

Renal Excretion of N4-Acetyl Sulphanilamide and N4-Acetyl Sulphadimidine in Goats

Renal ekskretion af N4-acetylsulfanilamid og N4-acetylsulfadimidin hos geder

Sigrid Tue Jørgensen 1,✉, Poul Nielsen 1,✉, Folke Rasmussen 1,✉
PMCID: PMC8407239  PMID: 4854108

Abstract

The renal excretion of N4-acetyl sulphanilamide and N4-acetyl sulphadimidine was studied in 19 experiments with 6 goats during continuous intravenous administration of the 2 sulphonamide derivatives. Deacetylation of both compounds takes place to a small extent only. Further it is shown that both sulphonamide derivatives are bound to plasma proteins to a greater extent than sulphanilamide and sulphadimidine. The excretion of the N4-acetylated sulphonamides is compared with the renal excretion of creatinine. The non-protein-bound fraction of the 2 N4-acetylated sulphonamides is excreted by filtration and active tubular secretion. The renal clearances of the acetyl derivatives are higher than those of the parent compounds.

Keywords: renal excretion, sulphonamides, N4-acetyl sulphanilamide, N4-acetyl sulphadimidine, proteinbinding, deacetylation

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