Table 3.
Specific activity of KDAC8 with biologically relevant putative KDAC substrates.
| Substrate | Source protein | UniProtKB | Ref. | Specific activity (s−1)* |
|---|---|---|---|---|
| SVRKacGIM | Cell death activator CIDE-3 | Q96AQ7 | 45 | 0.0036 ± 0.0008 |
| AARKacSAP | Histone H3.1 | P68431 | 47 | 0.0026 ± 0.0002 |
| APRKacQLA | Histone H3.1 | P68431 | 46 | 0.00163 ± 0.00014 |
| GVGKacYIN | RING-type E3 ubiquitin-protein ligase PPIL2 | Q13356 | 44 | 0.0007 ± 0.0004 |
| PEAKacSLL | RAC-alpha serine/threonine-protein kinase | P31749 | 41 | - |
| TGGKacAPR | Histone H3.1 | P68431 | 16,46 | - |
| LSGKacGNP | Catenin beta-1 | P35222 | 42 | - |
| GALKacAPS | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | O60566 | 43 | - |
| LGGKacQRA | Retinoic acid-induced protein 1 | Q7Z5J4 | 44 | - |
| EIGKacTLA | Zinc finger Ran-binding domain-containing protein 2 | O95218 | 44 | - |
| EVGKacLLN | Centromere protein F | P49454 | 44 | - |
| QTAKacDAG | Heat shock 70 kDa protein 1A/1B | P0DMV8, P0DMV9 | 48 | - |
| GTAKacSVT | Cellular tumor antigen p53 | P04637 | 49-51 | - |
| ITGKacPSG | Serine/threonine-protein kinase TBK1 | Q9UHD2 | 52 | - |
| SHLKacAHL | Transcription factor Sp7 | Q8TDD2 | 53 | - |
*
- indicates no activity above the limit of reliable detection (0.0004 s−1).