Association of Local Therapy With Quality-of-Life Outcomes in Young Women With Breast Cancer

Key Points

Question

What is the longer-term association of surgery with quality of life in young breast cancer survivors?

Findings

In this cross-sectional study of a prospective cohort, unilateral or bilateral mastectomy with radiotherapy (vs breast-conserving therapy) was associated with decreased breast satisfaction and psychosocial and sexual well-being.

Meaning

These findings suggest that more extensive surgery is associated with poorer quality-of-life outcomes in young breast cancer survivors, particularly those treated with mastectomy and radiotherapy, irrespective of reconstruction.

Abstract

Importance

Increasing rates of bilateral mastectomy have been most pronounced in young women with breast cancer, but the association of surgery with long-term quality of life (QOL) remains largely unknown.

Objective

To examine the association of surgery with longer-term satisfaction and QOL in young breast cancer survivors.

Design, Setting, and Participants

This multicenter cross-sectional study of a prospective cohort was conducted from October 2016 to November 2017, at academic and community hospitals in North America. Women 40 years or younger enrolled in the Young Women’s Breast Cancer Study were assessed. Data analysis was performed from during a 1- to 2-year period after conclusion of the study.

Exposures

Primary breast surgery, reconstruction, and radiotherapy.

Main Outcomes and Measures

Mean BREAST-Q breast satisfaction and physical, psychosocial, and sexual well-being scores were compared by type of surgery; higher BREAST-Q scores (range, 0-100) indicate better QOL. Linear regression was used to identify demographic and clinical factors associated with BREAST-Q scores for each domain.

Results

A total of 560 women with stage 0 to III breast cancer (median age at diagnosis, 36 years; range, 17-40 years; 484 [86%] with stage 0-II disease) completed the BREAST-Q a median of 5.8 years (range, 1.9-10.4 years) from diagnosis. A total of 290 patients (52%) of patients underwent bilateral mastectomy, 110 patients (20%) underwent unilateral mastectomy, and 160 patients (28%) received breast-conserving therapy. Among mastectomy patients, 357 (89%) had reconstruction and 181 (45%) received radiotherapy. In multivariate analyses, implant-based reconstruction (vs autologous) was associated with decreased breast satisfaction (β = −7.4; 95% CI, −12.8 to −2.1; P = .007) and complex reconstruction (vs autologous) with worse physical well-being (β = −14.0; 95% CI, −22.2 to −5.7; P < .001).

Conclusions and Relevance

These results suggest that local therapy in young breast cancer survivors is persistently associated with poorer scores in multiple QOL domains, particularly among those treated with mastectomy and radiotherapy, irrespective of breast reconstruction. Socioeconomic stressors also appear to play a role.

This cross-sectional study of young breast cancer survivors assesses whether mastectomy is associated with poor quality-of-life outcomes.

Introduction

Breast cancer is the most common cancer diagnosed in women younger than 40 years, accounting for 7% of all cancers diagnosed in the US annually.¹ It is widely established that choice of surgery (ie, breast conservation vs mastectomy) is not associated with overall survival, even among young women.^2,3 Historically, there has been concern that young women may experience higher rates of locoregional recurrence if electing to undergo breast conservation. More recent data have demonstrated excellent local control in young women undergoing both breast conservation and mastectomy, with local recurrence rates of 1% to 12% even in the absence of optimal systemic therapy.^4,5,6,7 Despite this finding, rates of mastectomy, and particularly bilateral mastectomy, have continued to increase in young women and have been reported to be as high as 35% to 40% in the US.^8,9

Given equivalent oncologic outcomes after breast cancer surgery in young women, quality of life (QOL) outcomes are of critical importance. Older studies^10,11 found small differences that favored breast conservation over mastectomy with regard to QOL in women of all ages. More recent data suggest that patients undergoing contralateral prophylactic mastectomy may experience higher satisfaction with the appearance of their breast(s) vs unilateral mastectomy.¹² Younger women are increasingly likely to pursue bilateral mastectomy for treatment of a unilateral breast cancer and are more likely to undergo breast reconstruction.⁹ They also experience higher levels of distress and are at increased risk for poorer psychosocial outcomes after a breast cancer diagnosis.¹³ Compounding this, young women have a higher likelihood of receiving adjuvant therapies, such as chemotherapy and postmastectomy radiotherapy, which have also been demonstrated to be negatively associated with QOL.^14,15

Data are limited regarding the association of surgery with longer-term satisfaction and QOL in young breast cancer survivors, particularly in the era of increasing bilateral mastectomy. To promote shared decision-making and choices that align with patients’ values and preferences, information about long-term outcomes after breast surgery in young women is needed. Using a multicenter, prospective cohort of young women with breast cancer, we sought to compare QOL among women who received breast-conserving therapy (BCT), unilateral mastectomy, and bilateral mastectomy as well as to evaluate differences by type of reconstruction among women who pursued unilateral mastectomy or bilateral mastectomy. We also sought to identify demographic and other treatment-related factors associated with QOL after breast cancer treatment.

Methods

Study Design and Population

The Young Women’s Breast Cancer Study (YWS) is a multicenter, prospective cohort study conducted from October 10, 2016, to November 31, 2017, to examine biological, medical, and QOL issues in women diagnosed with primary invasive breast cancer or ductal carcinoma in situ at 40 years or younger. Participating sites include academic and community hospitals in the Massachusetts region and 3 additional sites in Toronto, Canada; Colorado; and Minnesota. During a 10-year period (October 10, 2006, to June 30, 2016), 2162 eligible women were identified through pathology record review or review of clinic lists at participating hospitals and invited to participate in the YWS. A total of 1302 patients provided written informed consent, of whom 4 were found to be ineligible after enrollment and 1 withdrew consent after enrollment. Participants are sent a survey at study baseline (median of 5 months after diagnosis) followed by additional surveys twice a year for the first 3 years after diagnosis and annually thereafter. All data were deidentified. Data analysis was performed from during a 1- to 2-year period after conclusion of the study. The YWS is approved by the institutional review board at the Dana Farber-Harvard Cancer Care Center and other participating sites. Study design details have been previously reported.¹⁶ The study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.

BREAST-Q Substudy

Beginning in 2016, the BREAST-Q, a well-validated breast surgery–specific instrument focused on satisfaction with outcomes and health-related QOL,¹⁷ was sent to a subset of 743 YWS participants as a part of their 10-year follow-up or as a stand-alone survey. We excluded from the substudy population those participants who filled out only a short-form survey (eg, all patients enrolled in Toronto, n = 91), those who were deceased or lost to follow-up (n = 411), and those with confirmed recurrence or who presented with de novo stage IV disease (n = 52).

The BREAST-Q includes separate modules for BCT, mastectomy without reconstruction, and mastectomy with reconstruction and evaluates the following 6 different domains: satisfaction with breasts (breast appearance in terms of size, texture, and appearance in and out of clothes), psychosocial well-being (body image, confidence in social settings, emotional health, and self-esteem), physical well-being (pain or tightness in the breast area and difficulty with mobility or activities), sexual well-being (feelings of attractiveness and confidence as related to breasts and comfort during sexual activity), satisfaction with overall outcome, and satisfaction with care (information, medical team, surgeon, and office staff). We elected not to use satisfaction with overall outcome and satisfaction with care given time elapsed between surgery and completion of the questionnaires. Each domain is scored independently on a scale of 0 to 100, with higher scores representing a more favorable outcome. Minimally important differences in BREAST-Q scores are noted as the following: small, 2 to 3 points; moderate, 4 to 7 points; and large, 8 to 10 points.¹⁸

Patient, Disease, and Treatment Characteristics

Patient characteristics collected through the baseline survey included race and ethnicity (supplemented by medical record review if not reported or if baseline survey data were not available), employment status, perceived financial comfort level,^19,20 and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) at diagnosis. Given the small numbers of patients who were races other than White (2 [0.4%] American Indian or Alaska Native; 32 [6%] Asian; 17 [3%] Black, Haitian, or African American; and 3 [1%] unknown), race and ethnicity were dichotomized (White vs other race), allowing us to explore potential differences between White women and women from other racial and ethnic groups. Pathology and medical records of all patients were reviewed for stage of disease, hormone receptor, and ERBB2 (formerly HER2 or HER2/neu) status. We used 1-year survey data together with medical record review to determine genetic testing status and results. Surgery, chemotherapy, and radiotherapy information (yes/no) was also obtained by self-report in combination with medical record review. Reconstruction was defined as implant, autologous, or complex (combination of implant and autologous). Endocrine therapy use was based on self-report on any survey completed. Self-reported lymphedema at 1 year was assessed with a question about experiencing arm swelling from the Breast Cancer Prevention Trial Symptom Checklist.²¹

Statistical Analysis

We calculated numbers (percentages) for categorical covariates and means (ranges) for continuous covariates. Unadjusted mean BREAST-Q scores for each domain were compared using analysis of variance between the following local therapy groups: BCT, unilateral mastectomy with and without radiotherapy, and bilateral mastectomy with and without radiotherapy. Among the subset of women who had mastectomy with reconstruction, we compared unadjusted mean BREAST-Q scores between women undergoing implant-based reconstruction with and without radiotherapy, autologous tissue reconstruction with and without radiotherapy, and complex reconstruction. Univariate and multivariate linear regression was used to identify independent factors associated with BREAST-Q scores for each domain. Variables with a 2-tailed P ≤ .20 in univariate analyses were entered into the multivariate model, and stepwise model selection based on Akaike Information Criterion was used to create the final multivariate model. All analyses were conducted using R software, version 4.0.4 (R Foundation for Statistical Computing).

Results

Patient and Treatment Characteristics

Of the 743 participants sent the BREAST-Q, 584 completed the survey (response rate, 79%) as a part of their 10-year follow-up (n = 59) or as a stand-alone survey (n = 525). After excluding patients who completed a version of the BREAST-Q that did not match the surgery received (n = 3) and patients who had confirmation of a recurrence (n = 16) or new primary tumor (n = 5) after the BREAST-Q was sent, 560 patients (median age at diagnosis, 36 years; range, 17-40 years; 484 [86%] with stage 0-II disease) were included in the analytic cohort (eFigure in the Supplement). The median time from diagnosis to BREAST-Q completion was 5.8 years (range, 1.9-10.4 years). Patient characteristics are detailed in the Table. Most patients were White, were married, reported being financially comfortable, and had a college education. At study baseline, 336 (60%) had a BMI in the normal range (18.5 to 24.9), and 179 patients (32%) had a BMI of 25 or higher. Sixty-four patients (11%) tested positive for a BRCA (OMIM 113705) or p53 (OMIM 191170) mutation; test results were negative for 418 patients (75%). A total of 214 patients (38%) had stage I breast cancer, and 216 (39%) had stage II breast cancer. A total of 407 patients (73%) received chemotherapy, and 372 patients (66%) reported current or past use of endocrine therapy.

Table. Patient and Treatment Characteristics.

Characteristic	No. (%) (N = 560)
BMI at first survey
<18.5	25 (4)
18.5-24.9	336 (60)
≥25	179 (32)
Missing	20 (4)
Race or ethnicity
White	506 (90)
Other	54 (10)
American Indian or Alaska Native	2 (0.4)
Asian	32 (6)
Black, Haitian, or African American	17 (3)
Unknown	3 (1)
Marital status
Married or living as married	429 (77)
Single, divorced or widowed	113 (20)
Missing	18 (3)
Financial status
Comfortable	445 (79)
Uncomfortable	90(16)
Missing	25 (5)
Work status
Work full time	344 (62)
Other	19 (3)
Missing	197 (35)
Educational level
Some college, college graduate, or postcollege work	479 (86)
Other (grade school/junior high and some high school, high school graduate, and technical/vocational school)	64 (11)
Missing	17 (3)
Genetic testing for BRCA and p53
Negative result	418 (75)
Positive result	64 (11)
No record of testing	78 (14)
Stage
0	54 (10)
I	214 (38)
II	216 (39)
III	76 (13)
Chemotherapy
Yes	407 (73)
No	153 (27)
Endocrine therapy
Yes	372 (66)
No	188 (34)
Time since surgery, y
1-5	218 (39)
>5	342 (61)
Surgery
Breast-conserving therapya	160 (28)
Mastectomy
Unilateral	110 (20)
Bilateral	290 (52)
Axillary surgery
Sentinel node biopsy	336 (60)
Sentinel node biopsy and axillary dissection	123 (22)
Axillary lymph node dissection	86 (15)
No axillary surgery	13 (2)
Missing	2 (0)
Postmastectomy radiotherapy (n = 399)	181 (45)
Lymphedema at 1 y
Yes	163 (29)
No	397 (71)
Reconstruction (among patients undergoing mastectomy) (n = 400)
No reconstruction	42 (11)
Implant-based reconstruction	288 (72)
Autologous reconstruction	56 (14)
Complex reconstruction	13 (3)
Unknown	1 (0)

Abbreviation: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared).

^aOnly 1 patient who received breast-conserving therapy did not receive radiotherapy.

Details related to local therapy, including surgery, radiotherapy, and lymphedema are described in the Table. A total of 290 patients (52%) underwent bilateral mastectomy, 110 patients (20%) underwent unilateral mastectomy, and 160 patients (28%) received BCT. A total of 181 patients (45%) who had mastectomy received radiotherapy. Most patients had axillary surgery performed, with 336 (60%) receiving sentinel lymph node biopsy only, 123 patients (22%) having sentinel lymph node biopsy and completion axillary lymph node dissection, and 86 patients (15%) having axillary lymph node dissection. Lymphedema was self-reported by 163 patients (29%) at 1 year.

Of patients undergoing mastectomy, 357 (89%) also underwent reconstruction (eTable 1 in the Supplement). In this group, 56 patients (16%) had autologous reconstruction, 288 patients (81%) had implant reconstruction, and 13 patients (3%) had complex reconstruction. A total of 17 patients reported reconstruction after lumpectomy, but these patients were excluded from the reconstruction subset analysis.

Local Therapy BREAST-Q Outcomes

Unadjusted mean BREAST-Q scores by local therapy strategy are shown in Figure 1. Satisfaction with breasts, psychosocial well-being, and sexual well-being all differed by local therapy strategy (global P < .001), with scores across these domains highest in women who had BCT (breast satisfaction score, 65.5; psychosocial well-being score, 75.9; and sexual well-being score, 57.4) and lowest among women who had unilateral or bilateral mastectomy with radiotherapy (breast satisfaction score, 54.6 unilateral and 55.8 bilateral; psychosocial well-being score, 66.1 unilateral and 65.1 bilateral; and sexual well-being score, 50.4 unilateral and 46.2 bilateral) vs those without radiotherapy (breast satisfaction: 64.3 unilateral and 64.0 bilateral; physical well-being: 80.5 unilateral and 80.2 bilateral; psychosocial well-being: 75.2 unilateral and 71.3 bilateral; and sexual well-being: 56.6 unilateral and 51.4 bilateral). No significant differences were found by local therapy strategy in physical well-being scores (BCT, 78.9; bilateral mastectomy without radiotherapy, 80.2; bilateral mastectomy with radiotherapy, 76.8; unilateral mastectomy without radiotherapy, 80.5; unilateral mastectomy with radiotherapy, 77.4; P = .31).

Figure 1. Unadjusted BREAST-Q Mean Scores by Local Therapy Strategy.

BCT indicates breast-conserving therapy; BMx, bilateral mastectomy; RT, radiation therapy; UMx, unilateral mastectomy.

Breast Satisfaction

Factors independently associated with lower breast satisfaction (Figure 2A) on multivariate analysis included financial discomfort (β = −5.1; 95% CI, −9.5 to −0.7; P = .02), unilateral mastectomy with radiotherapy (vs BCT; β = −9.8; 95% CI, −15.8 to −3.9; P = .001), and bilateral mastectomy with radiotherapy (vs BCT; β = −8.8; 95% CI, −13.4 to −4.2; P < .001). Stage III (vs stage I) and presence of lymphedema were associated with lower breast satisfaction only in univariate analyses. Other demographic, clinical, and treatment covariates were not associated with breast satisfaction (eTable 2 in the Supplement).

Figure 2. Patient and Treatment Factors Associated With BREAST-Q Scores.

Error bars indicate 95% CIs. BCT indicates breast-conserving therapy; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); RT, radiation therapy.

Physical Well-being

Longer time since surgery (>5 vs ≤5 years) was independently associated with better physical well-being (β = 6.1; 95% CI, 3.6-8.6; P < .001), whereas financial discomfort (β = −4.9; 95% CI −8.1 to −1.6; P = .004) and presence of lymphedema (β = −6.1; 95% CI, −8.8 to −3.5; P < .001) were independently associated with worse physical well-being (Figure 2B). Other demographic, clinical, and treatment covariates were not associated with physical well-being (eTable 3 in the Supplement).

Psychosocial Well-being

Factors independently associated with worse psychosocial well-being (Figure 2C) included financial discomfort (β = −7.0; 95% CI, −11.6 to −2.4; P = .003), BMI of 25 or higher (vs BMI of 18.5-24.9; β = −4.2; 95% CI, −8.0 to −0.52; P = .03), unilateral mastectomy with radiotherapy (β = −9.5; 95% CI, −15.7 to −3.3; P = .003), bilateral mastectomy without radiotherapy (β = −4.8; 95% CI, −9.3 to −0.32; P = .04), and bilateral mastectomy with radiotherapy (β = −10.5; 95% CI, −15.1 to −5.5; P < .001). Lymphedema and time since surgery were associated with worse psychosocial well-being only in univariate analyses. Other demographic, clinical, and treatment covariates were not associated with psychological well-being (eTable 4 in the Supplement).

Sexual Well-being

Factors independently associated with worse sexual well-being (Figure 2D) included BMI of 25 or higher (vs BMI of 18.5-24.9; β = −5.1; 95% CI, −8.9 to −1.4; P = .008), financial discomfort (β = −6.7; 95% CI, −11.3 to −2.0; P = .005), unilateral mastectomy with radiotherapy (β = −6.4; 95% CI −12.8 to −0.1; P = .05), bilateral mastectomy without radiotherapy (β = −6.4; 95% CI, −10.9 to −1.8; P = .006), and bilateral mastectomy with radiotherapy (β = −10.4; 95% CI, −15.3 to −5.5; P < .001). Lymphedema was associated with worse sexual well-being only on univariate analyses. Other demographic, clinical, and treatment covariates were not associated with sexual well-being (eTable 5 in the Supplement).

BREAST-Q Outcomes After Reconstruction

To understand whether there were differences in QOL among women who had mastectomy with breast reconstruction, we performed similar analyses among this subgroup. Unadjusted mean BREAST-Q scores by reconstruction type among women who had mastectomy with reconstruction (n = 357) are shown in Figure 3. Satisfaction with breasts, physical well-being, and psychosocial well-being all differed by local therapy strategy, with scores across these domains highest in women who had autologous reconstruction without radiotherapy and lowest among women who had implant reconstruction with radiotherapy or complex reconstruction. No significant differences were found by reconstruction type seen in sexual well-being scores (autologous without radiotherapy, 54.2; autologous with radiotherapy, 49.6; implant without radiotherapy, 51.9; implant without radiotherapy, 46.7; complex, 47.7; P = .26).

Figure 3. Unadjusted BREAST-Q Mean Scores by Reconstruction Type.

RT indicates radiation therapy.

In multivariate analyses (Figure 4), implant-based reconstruction (vs autologous) was associated with decreased breast satisfaction (β = −7.4; 95% CI, −12.8 to −2.1; P = .007) and complex reconstruction (vs autologous) with worse physical well-being (β = −14.0; 95% CI, −22.2 to −5.7; P < .001). Reconstruction type was not associated with psychosocial or sexual well-being, and bilateral mastectomy, delayed vs immediate reconstruction, use of tissue expander, and use of symmetry procedure were not associated with BREAST-Q scores on univariate or multivariate analysis. Other statistically significant factors associated with BREAST-Q scores (across all domains) among the subset of women who had reconstruction were largely consistent with results of the local therapy models (eTable 6 in the Supplement).

Figure 4. Patient and Treatment Factors Associated With BREAST-Q Score Among Women Who Underwent Mastectomy With Reconstruction.

Error bars indicate 95% CIs. BMI indicates body mass index.

Discussion

In this multicenter prospective cross-sectional study of a cohort of young women diagnosed with breast cancer, moderate to large QOL differences by local therapy strategy were apparent several years after surgery, with women who underwent more extensive surgery, particularly when combined with radiotherapy, having lower QOL largely driven by inferior satisfaction with breasts and psychosocial and sexual well-being. These findings are all the more striking considering the recent trends toward bilateral mastectomy for unilateral breast cancer and the fact that most of these women underwent reconstruction.

Several prior studies,^12,22 inclusive of women of all ages, have used the BREAST-Q to evaluate health-related QOL after breast cancer surgery. Findings from a cross-sectional analysis²² of 7619 women of all ages recruited through the Army of Women research registry an average of 6.7 years after surgery were similar to those of our study, with higher scores indicating better QOL among women who underwent BCT or mastectomy with autologous reconstruction and lower scores among women having implant-based reconstruction, complex reconstruction, or mastectomy with no reconstruction. This study²² reported slightly larger differences in breast satisfaction scores, which were a mean of 8.6 points lower among women who had implant-based reconstruction than among those who had BCT; we found a more modest difference (5.6 points lower) in women who underwent mastectomy with implant-based reconstruction compared with women who underwent BCT. Findings of decreased breast satisfaction for women who undergo mastectomy, particularly for those receiving postmastectomy radiotherapy after implant-based reconstruction, are concerning given the large numbers of young women who choose bilateral mastectomy for a unilateral early breast cancer in combination with the recent trend of increasing rates of postmastectomy radiotherapy for young patients with breast cancer.¹⁵

For certain BREAST-Q domains, mean scores in our study were lower than those reported in other studies,^12,23 supporting previous data demonstrating poorer psychosocial outcomes in younger patients. In a recently published single-institution study²³ that followed up 3233 women (median age, 53 years) with early-stage breast cancer, psychosocial and sexual well-being scores improved in both the BCT and mastectomy groups during the follow-up period and were higher at all time points, indicating better QOL, when compared with the scores in our study. Similarly, compared with BREAST-Q scores of 3977 women from the Army of Women study¹² (mean age, 57 years) who underwent mastectomy, psychosocial well-being in our study was slightly lower among women who underwent unilateral mastectomy (73.9 vs 70.6) and bilateral mastectomy (71.7 vs 68.4). In contrast, sexual well-being scores were similar after bilateral mastectomy (48.6 vs 49.0) and modestly better in our study after unilateral mastectomy (50.0 vs 53.4).¹² Physical well-being scores were also slightly higher for patients in our study after unilateral mastectomy (76.8 vs 78.9) and bilateral mastectomy (74.5 vs 78.7),¹² perhaps attributable to the younger age of women in our cohort and a decreased likelihood of experiencing age-related comorbidities that may affect physical functioning.²⁴

In addition to surgical type, it is not surprising that other clinical factors, such as weight and lymphedema, are negatively associated with QOL as well. Identification of these risk factors may enable intervention at an early stage, ultimately decreasing the potential for long-term QOL sequelae after breast cancer. Perhaps most profound was the association with perceived financial status, which was associated with lower QOL across all domains. Others^25,26 have similarly documented an association between financial hardship and QOL and speak to the need to further address issues of financial toxicity among young patients, as well as challenges experienced by patients from socioeconomically disadvantaged backgrounds.

Limitations

This study has limitations. This was a cross-sectional, 1-time survey of a prospective cohort; thus, we do not have these particular measures over time, including true prediagnosis or preoperative baseline. Baseline QOL may drive surgical choices as well as postoperative QOL. In addition, we did not examine candidacy for BCT compared with definitive surgical procedure, although previous work²⁷ has demonstrated that factors associated with undergoing bilateral mastectomy vs lumpectomy are similar even when restricted to patients who reported that their physician said that lumpectomy was an option or was recommended to them. It is possible that women who chose mastectomy because of personal preference may perceive their QOL differently than women who underwent mastectomy because they were not candidates for BCT. The generalizability of these findings may also be limited because our cohort is mostly White and of higher socioeconomic status. Nevertheless, patient-reported outcomes can provide essential QOL information and help identify potential areas of need for intervention during survivorship.

Conclusions

Although most young women report satisfaction with their treatment decisions, some women have regrets,²⁸ underscoring the relevance of data that reflect the long-term, patient-reported, postoperative experience. The current study identified a negative association between more extensive surgery, particularly when radiotherapy is indicated, and QOL for young women with breast cancer several years after surgery. Consideration should be given to including QOL data as part of decision support tools for young women with newly diagnosed breast cancer as well as in physician discussions with patients to ensure young women understand the long-term impacts of surgery with and without radiotherapy, which is of particular importance given the extended survivorship period most young patients experience after breast cancer surgery.

Supplement.

eFigure. Study Flow Diagram

eTable 1. Local Therapy Characteristics for Reconstruction Patients (N = 357^a)

eTable 2. Univariate and Multivariate Analysis: Association of Patient and Treatment Factors With BREAST-Q Breast Satisfaction Domain Score

eTable 3. Univariate and Multivariate Analysis: Association of Patient and Treatment Factors With BREAST-Q Physical Domain Score

eTable 4. Univariate and Multivariate Analysis: Association of Patient and Treatment Factors With BREAST-Q Psychosocial Domain Score

eTable 5. Univariate and Multivariate Analysis: Association of Patient and Treatment Factors With BREAST-Q Sexual Domain Score

eTable 6. Multivariate Analysis of Patient and Treatment Factors Associated With BREAST-Q Domain Scores Among Patients Who Had Mastectomy With Reconstruction