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. 2021 Jul 17;40(35):5403–5415. doi: 10.1038/s41388-021-01948-6

Fig. 3. UBE2CP3 promotes GC cell growth and metastasis in vitro and in vivo.

Fig. 3

A The knockdown efficiency of UBE2CP3 in GC cell lines was verified by qRT-PCR assay. The P values were estimated using one-way ANOVA test. B Knockdown of UBE2CP3 significantly promoted cell apoptosis rate of GC cell lines. C, D The effects of UBE2CP3 knockdown on GC cells migration were assessed by wound healing assay in GC cell lines. E, F The effects of UBE2CP3 knockdown on GC cells migration and invasion were assessed by transwell assay in GC cell lines. G, H The effects of UBE2CP3 overexpression on the migration and invasion of GC cells were assessed by wound healing assay and transwell assay. I, J The weight and volume of harvested transplanted tumors were measured. K The effect of UBE2CP3 overexpression and depletion on the expression of EMT biomarkers was determined in different GC cell lines by western blotting. The scale bars in wound healing assay and transwell assay represent 100 μm and 25 μm, respectively. NC negative control. The P values were estimated using two-tailed t test. **P < 0.01.