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. 2021 Aug 31;9:e12072. doi: 10.7717/peerj.12072

Figure 5. Src is the most likely target molecule for direct binding by daidzein.

Figure 5

(A) Network of daidzein-target genes. Purple diamonds represent daidzein; green circles represent target genes of daidzein. (B) Venn diagram revealing the common target genes of daidzein against osteosarcoma. (C) Protein-protein interaction (PPI) network. Nodes: common targets of daidzein and osteosarcoma; Edges: PPIs between targets of daidzein and their interaction partners. (D) The top 30 hub genes in the PPI network that interacted with the most numerous edges. (E) The Ball and Stick 3D structure of daidzein. The gray ball represents the carbon atom when the red ball represents the oxygen atom, and the small white ball represents the hydrogen atom. (F) Molecular docking simulation predicted the amino acid residues bound by daidzein. (G) Molecular docking simulation of daidzein to Src protein. Sticks represent the three-dimensional structure of daidzein; the surface represents the protein structure of Src protein.