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The MspA nanopore assay for DUB activity. A) Schematic showing ubiquitin (Ub, PDB: 1UBQ[11]) interacting with the MspA nanopore (M2-MspA-NNN,[12] adapted from PDB: 1UUN[13]) under a positive trans voltage. Current through MspA is recorded, transient blockages in the current indicate MspA: Ub interactions. B) Ub trimer (tri-Ub) substrate is broken down into a Ub dimer (di-Ub) and a Ub monomer product by the DUB UCH37 ·RPN13 (PDB: 4UEM[14]).
