Correction to: Clinical Pharmacokinetics (2020) 59:1273–1290 10.1007/s40262-020-00888-w
In Table 8 of this article, the data in the column headed “Fed Geometric LS Mean” were mistakenly listed under column heading “Fasted Geometric LS Mean”and vice versa.
Table 8.
Effects of food on the pharmacokinetic (PK) profile of gilteritinib
| PK parameter | N | Fasted GLSM | Fed GLSM | GMR (%)a | 90% CI (%)a |
|---|---|---|---|---|---|
| AUCinf (ng•h/mL) | 16 | 1900 | 1780 | 93.8 | 81.2–108.4 |
| AUClast (ng•h/mL ) | 16 | 1840 | 1740 | 94.6 | 81.8–109.3 |
| AUC72 (ng•h/mL) | 16 | 951 | 865 | 91.0 | 78.2–105.9 |
| Cmax (ng/mL) | 16 | 28.6 | 21.2 | 74.0 | 62.2–88.1 |
AUC72 area under the concentration–time curve from the time of dosing to 72 h post-dose, AUCinf area under the concentration–time curve from the time of dosing extrapolated to time infinity, AUClast area under the concentration–time curve from the time of dosing to the last measurable concentration, CI confidence interval, Cmax maximum observed concentration, GLSM geometric least-squares mean, GMR geometric mean ratio
aAssessment based on an analysis of variance performed on natural log-transformed parameters with the food condition as a fixed effect. Ratios and confidence limits are transformed back to raw scale and values are expressed as percentages. The ratio denotes the gilteritinib 40-mg fed GSLM estimate divided by the gilteritinib 40-mg fasted GLSM estimate
The correct Table 8 is as follows: