Fig. 3.

(a) The impact of degradation rate of PGS and its derivative derivatives on host remodeling of vascular grafts. PGS is less hydrophobic and degrades fast in vivo. The PGS graft presents a less stable and relatively fast receding interface with host cells. This could explain why the graft dilates. PPGS is more hydrophobic and degrades slower in vivo. The more stable interface leads to the maintenance of the luminal tissues. Here we use commercially available PGS (Regenerez®) that has a lower molecular weight and degrades faster than PGS used in our previous studies that is synthesized in house [29]. (b) H&E staining of three different types of grafts explanted in week 4 and 12 under polarized light.