Table 1.
Genes affected by Zbed6 knockout in mice. Validations from in vitro beta cell studies were also included
| Cellular process | Gene symbol | Gene name | Comment/Reference |
|---|---|---|---|
| Insulin production | Ins1 | Insulin 1 | Upregulated [4, 6] |
| Ins2 | Insulin 2 | Upregulated [4, 6] | |
| Pcsk2 | Proprotein convertase subtilisin/kexin type 2 | Upregulated | |
| Slc2a2 | Solute carrier family 2 (facilitated glucose transporter), member 2 | Upregulated | |
| Transcription factors | Nkx6-1 | NK6 homeobox 1 | Upregulated [6] |
| Foxo1 | Forkhead box O1 | Upregulated | |
| Pax6 | Paired box gene 6 | Upregulated [6] | |
| Cell cycle | Pttg1 | Pituitary tumour-transforming gene 1 | Downregulated |
| Ccnc | Cyclin C | Downregulated | |
| Beta cell autoantigens | Ins1/2 | Insulin 1/Insulin 2 | Upregulated |
| Slc30a2 | Solute carrier family 30 (zinc transporter), member 8 | Upregulated | |
| Ica1 | Islet cell autoantigen 1 | Upregulated | |
| Gad1 | Glutamic acid decarboxylase 1 | Upregulated | |
| Ptprn2 | Protein tyrosine phosphatase, receptor type, N polypeptide 2 | Upregulated | |
| Cell–cell contacts | Cdh1 | Cadherin 1 (E-cadherin) | Downregulated [5] |
| Cdh2 | Cadherin 2 (N-cadherin) | Upregulated [5] | |
| cAMP-signalling | Adcy9 | Adenylate cyclase 9 | Upregulated [6] |
| Mitochondrial ROS | Romo1 | Reactive oxygen species modulator 1 | Upregulated |
| Ucp2 | Uncoupling protein 2 (mitochondrial, proton carrier) | Upregulated | |
| Miscellaneous: | Igf2 | Insulin-like growth factor 2 | Upregulated |
| Zbed6 | Zinc finger, BED-type containing 6 | Downregulated |