Figure 1.

Proteomic and phosphopeptide lineage specific profiling of primary mammary epithelial cells

(A) Flowchart of experimental workflow.

(B) Venn diagram of quantified proteins and phosphopeptides across datasets.

(C–F) Overview of proteins' and phosphopeptides' log2 fold changes (old vs young) in selected functional protein classes (young: from women <30 years (n = 5), old: >50 years old (n = 5)) Filtered by category members using curated publicly available datasets (Key Resource Table). Phosphopeptide data is shown on peptide level and filtered by masterprotein.

(G) KRT14 and KRT19 expression as a function of age in luminal epithelial (LEp) cells.

(H) ZNF542P and AVIL expression as a function of age in myoepithelial (MEp) cells.