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. 2021 Sep 9;11:18377. doi: 10.1038/s41598-021-97918-9

Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Erika Castillo 1, Julio Leon 1,8, Guianfranco Mazzei 1, Nona Abolhassani 1, Naoki Haruyama 1, Takashi Saito 2, Takaomi Saido 2, Masaaki Hokama 1,9,, Toru Iwaki 3, Tomoyuki Ohara 4, Toshiharu Ninomiya 5, Yutaka Kiyohara 6, Kunihiko Sakumi 1, Frank M LaFerla 7, Yusaku Nakabeppu 1,
PMCID: PMC8429626  PMID: 34504282

Correction to: Scientific Reports 10.1038/s41598-017-17999-3, published online 19 December 2017

This article contains errors in the Introduction, where

AppNL-G-F/NL-G-F mice carrying the homozygous mutant App gene encoding the humanised Aβ sequence (G601R, F606Y, and R609H) with three pathogenic mutations, namely Swedish (KM595/596NL), Beyreuther/Iberian (I641F), and Arctic (E618G)10, progressively exhibit Aβ accumulation starting at 4 to 6 months of age, dense distributions of microglia and astrocytes from 9 months of age, and behavioural symptoms from 8 to 12 months of age10,11.”

should read:

AppNL-G-F/NL-G-F mice carrying the homozygous mutant App gene encoding the humanised Aβ sequence (G676R, F681Y, and R684H) with three pathogenic mutations, namely Swedish (KM670/671NL), Beyreuther/Iberian (I716F), and Arctic (E693G)10, progressively exhibit Aβ accumulation starting at 4 to 6 months of age, dense distributions of microglia and astrocytes from 9 months of age, and behavioural symptoms from 8 to 12 months of age10,11.”

In addition, in the Methods section, under the subheading ‘Animals’,

“Heterozygous App+/NL-G-F mice carrying humanised Aβ sequence (G601R, F606Y, R609H), Swedish (ML595/596NL), Beyreuther/Iberian (I641F), and Arctic (E618G) mutations, were previously established10.”

should read:

“Heterozygous App+/NL-G-F mice carrying humanised Aβ sequence (G676R, F681Y, R684H), Swedish (KM670/671NL), Beyreuther/Iberian (I716F), and Arctic (E693G) mutations, were previously established10.”


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