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LDH-A activity promotes pneumococcal virulence. (A) Mice were infected intratracheally with 5.0 × 106 CFU of WU2 alongside recombinant LDH-A or nonfunctional point mutated LDH-A (R106Q). (B) Mice were infected intratracheally with 1.0 × 106 CFU EF3030 alongside different concentrations of lactate. Shapes in panels represent bacterial burden for each mouse. Statistical analyses were performed using a Kruskal-Wallis test with Dunn’s multiple-comparison posttest.
